The list of ships which have been lost at sea is a long one, the dangers are many and rescue is often not close at hand either. By far fire is the most deadly of all casualty causes, it takes more ships than any other cause. However, in many cases negligence places a significant role too and most casualties are rather a combination of factors. My list includes the more prominent casualties and when the incident occurred, it does however exclude ships lost during wartime. Many ships would fall under 1 or more categories as often they sink under tow after the disaster. It is still worthwhile noting that sea travel is relatively safe when compared to road accident deaths or aircraft accidents.
I was hoping to do an individual page on each ship as time passed, but never did, so I have included a link to an external relevant page where I can find one. Indicates that there is a relevant page for this disaster

Vessel Name	Date	Lives Lost	Region
Collision:
Republic/Florida	23-01-1909	4	Nantucket Coast
Titanic	14-04-1912	1500+	North Atlantic Ocean
Empress of Ireland/Storstad (External link)	29-05-1914	1024+	St Lawrence River
Andrea Doria/Stockholm (External link)	25-07-1956	46	North Atlantic
Admiral Nakhimov/Pyotr Vasev	31-08-1986	425	Black Sea
Dona Paz/Victor (External link)	20-12-1987	4000+	Philippines
Jupiter/Adige	21-10-1988	4	Greece
Moby Prince/Agip Abruzzio	11-04-1991	141	Livorno coast
Fire:
General Slocum	15-06-1904	1021+/-	Long Island Sound
Volturno	09-10-1913	163	North Atlantic Ocean
L'Atlantique	04-01-1933	12+	English Channel
Morro Castle (external link)	08-09-1934	124	New Jersey coast
Noronic	17-09-1949	118+	Toronto Harbour
Lakonia	19-12-1963	128	Madeira Coast
Yarmouth Castle	13-11-1965	87+	Bahamas
Seawise University	09-01-1972		Hong Kong
Angelina Lauro	30-03-1979	nil	US Virgin Islands
Prinsendam	04-10-1980	Nil	Alaska coast
Lavia	07-01-1989		Hong Kong
Scandinavian Star	07-04-1990	159	Skagerrak
Fiesta	14-10-1991		Greece
Pallas Athena	23-03-1994	Nil	Greece
Achille Lauro	30-11-1994	4	Somalia coast
Romantica	04-10-1997	nil	Mediterranean
Sun Vista	20-05-1999	nil	Malaysian coast
Galapagos Discoverer	20-10-1999		Panama
Al-Salam Boccaccio 98 (external link)	03-03-2006	1018 +/-	Red Sea
Strandings and storms:
Central America	12-09-1857	420+/-	Offshore Charleston
Principe de Asturias	05-03-1912	500+	Sebastian Point
Vestris	12-11-1928	110	Virginia Coast
Toya Maru (External link)	26-09-1954	1139+/-	Tsugaru Strait
Wahine (external link)	10-04-1968	51	Wellington Harbour, New Zealand
Caribia (Caronia)	12-08-1974		Apra Harbour, Guam
Edmund Fitzgerald (External link)	10-11-1975	29	Lake Superior
Derbyshire (External link)	09-09-1980	42	South of Japan
Columbus C	1984		Cadiz
Mikhail Lermontov (External link)	31-08-1986	1	New Zealand coast
Herald of Free Enterprise (External link)	06-03-1987	188	Zeebrugge
American Star	01-1994	Nil	Canary Islands
Express Samina (External link)	26-09-2000	63+	Mediterranean
Le Joola	26-09-2002	900+	Atlantic Ocean
Sea Diamond	06-04-2007	2?	Aegean Sea
Princess of the Stars	21/22 June 2008	700+?	Philippines (en route to Cebu)
Mechanical, Unknown, Other
Dara	08-04-1962	236	Persian Gulf
Heraklion	08-12-1966	230+	Between Crete & Piraeus
Oceanos	04-08-1991	Nil	South African coast
Bukoba	21-05-1996	1000+/-	Lake Victoria
Estonia	28-09-1994	852+	Baltic Sea
SeaBreeze	17-12-2000	Nil	North Atlantic Ocean
Princess Ashika	01-08-2009	+/-93	About 86km north-east of the Tongan capital Nuku'alofa.
Sank under tow:
Constitution	11-1997		Pacific Ocean
Belofin 1 (Britannis)	21-10-2000	Nil	South African coast
Sun (Regent Sun)	25-07-2001	Nil	South African coast
Sea (Regent Sea)	21-07-2001	Nil	South African coast
Copa Casino	16-03-2003	Nil	Dominican Rep. coast
Stella Polaris	02-09-2006	Nil	Japanese coast